Yes, but not when it is raining heavily or on weekends when there might be a jeep or motorcycle rally but the roadside lechonorias would be open. From highway 52 in Cayey to Highway 10 near Adjuntas and Ponce is nice. You would go through Aibonito, A spot where you can see the Atlantic Ocean and The caribbean. Toro Negro national forest with nice hiking trails and few people. Maravilla where you get awesome views of the Caribbean. It is nice above Mayagues, Maricao towards Yauco. Avoid the mountains at night, fog and rain. Dry winter days are best.